摘要
Abstract
Objective To explore the relationship between the T cell subsets and glucose level and first-phase insulin secretion function in patients with type 2 diabetes mellitus (T2DM). Methods We determined the oral glucose tolerance ( OGTT) , insulin release test (IRT) , body mass index ( BM1) , glycohemo-globin Al c (HbAl c) , T lymphocyte subsets ( CD4+ , CD8+ ) , and activity of natural kill ( NK) cell and △l30/ △G30 in 78 newly diagnosed T2DM patients, 60 impaired glucose tolerance (IGT) patients, and 60 normal controls. Results DM and IGT patients had significantly lower levels of CD4+ , CD4 VCD8 + ratio, activity of NK cell, and △I30/ A G30 and significantly higher levels of HbAl c and CD8 + compared with normal controls ( all P< 0.05) . Patients in DM group had significantly lower level of CD4 + , △ I30/Zl G30 and significantly higher levels of FBG and HbAlc compared with IGT group. There was no significant difference in terms of CD8 +, CD4+CD8+ ratio, and activity of NK cell between IGT and DM groups, whereas CD4+ T cells were negatively correlated with FBG and HbAlc and positively with △ I30/△C30 . Multipul regression stepwise analysis showed that CD4+ was independently associated with HbAlc and △I30/△G30. Conclusion T2DM patients tends lo have disorders in cellular immunity, which is correlated with blood glucose level and the insulin secretion function.关键词
2型糖尿病/T细胞亚群/胰岛素分泌功能Key words
type 2 diabetes mellilus/ T lymphocyte subsets/ insulin secretion function分类
医药卫生
