中国医学科学院学报2012，Vol.34Issue(3)：281-285,5.DOI:10.3881/j.issn.1000-503X.2012.03.019
Polycomb Group蛋白复合体与干细胞的发育调控
Polycomb Group Proteins and Their Roles in Regulating Stem Cell Development
摘要
Abstract
Polycomb group (PcG) proteins are a family of epigenetic regulators responsible for the repression of genes in proliferation and differentiation of stem cells. PcG protein complex consists of two important epigenetic regulators:PRC1 ( polycomb repressive complex 1) and PRC2 ( polycomb repressive complex 2). In order to further understand the functions of PcG proteins in stem cell growth and differentiation, we review the PcG protein composition, PcG protein localization in the target gene, PcG protein recruitment, and the functions of PcG proteins in the development of stem cells.关键词
Polycomb group蛋白/干细胞/基因沉默/表观遗传修饰Key words
Polycomb group proteins/ stem cells/ repression of genes/ epigenetic modification分类
医药卫生引用本文复制引用
黄冰洋,潘晓燕,李质馨,王正朝,于永生,窦肇华..Polycomb Group蛋白复合体与干细胞的发育调控[J].中国医学科学院学报,2012,34(3):281-285,5.基金项目
吉林省科技发展计划项目(201201077) （201201077）
