中国药业2012，Vol.21Issue(16)：35-37,3.
注射用青霉素钠与脂肪乳的配伍稳定性及体外抑菌活性检测
Compatibility Stability and in Vitro Antimicrobial Activity of Benzylpenicillin Sodium Injection with Lipid Emulsion
马玉樊 1赵雯 1王汝涛 1张志刚 1卢婷利 1陈涛1
作者信息
- 1. 西北工业大学生命学院空间生物实验模拟技术重点实验室,陕西,西安,710072
- 折叠
摘要
Abstract
Objectives To investigate the stability and in vitro antimicrobial activity in compatibility of benzylpenicillin sodium injection with 10% ,20% and 30% lipid emulsion, respectively. Methods The pH meter and the Zetasizer Nano ZS particle size analyzer were adopted to detect the pH value and the particle size of the compatible solution within 24 h at 25 ℃ and 4 ℃. The benzylpenicillin sodium in the compatible solution were determined by high performance liquid chromatographyC HPLC A The in vitro antimicrobial activity of compatible solution was investigated by the microdilution method. Results After compatibility of benzylpenicillin sodium injection with 10% ,20% and 30% lipid emulsion, there were no significant changes in the appearance, pH value, particle size and content of the compatible solution. The antimicrobial action of benzylpenicillin sodium was not affected. Conclusion The compatible solution of benzylpenicillin sodium injection respectively mixed with 10% ,20% and 30% lipid emulsion has good stability and conforms to the requirement of injection. So this compatibility may be applied.关键词
青霉素钠注射液/脂肪乳/配伍/稳定性/抑菌率Key words
benzylpenicillin sodium injection/lipid emulsion/compatibility/stability/antimicrobial rate
分类
医药卫生引用本文复制引用
马玉樊,赵雯,王汝涛,张志刚,卢婷利,陈涛..注射用青霉素钠与脂肪乳的配伍稳定性及体外抑菌活性检测[J].中国药业,2012,21(16):35-37,3.
