中国中医药信息杂志2012，Vol.19Issue(8)：38-40,3.DOI:10.3969/j.issn.1005-5304.2012.08.014
电针对老年痴呆大鼠海马 N-甲基-D-天冬氨酸受体1mRNA的影响
Effect of Electro-acupuncture on N-Methyl-D-aspartate Receptor 1 Messenger RNA in Hippocampus with Alzheimer's Disease
摘要
Abstract
Objective To observe the effect of electro-acupuncture on the expression of NMDAR1 mRNA in the hippocampus of rats with Alzheimer's disease (AD), and discuss the mechanism. Methods SD rats were randomly divided into 4 groups：the normal group, sham-operated group, model group, electro-acupuncture group. Bilateral hippocampus were injected condensed Aβ25-35 to make rat model of AD. Electro-acupuncture group were selected bilateral Shenshu points, bilateral Neiguan points and Dazhui points, treated by G6805-Ⅱ type electro-acupuncture therapeutic apparatus with the frequence of 2 Hz continuous wave and the intensity of 1 mA, lasting 20 min, one time per day, 6 times a week, for a total of two weeks. Hybridization in situ was used to detect NMDAR1 mRNA changes in hippocampus of each group and the effect of electro-acupuncture's intervention to NMDAR1 mRNA was analyzed. Results Compared with sham-operated group, NMDAR1 mRNA's expression of model group's hippocampus decreased obviously (P＜0.01). Compared with the model group, NMDAR1 mRNA's expression of electro-acupuncture group's hippocampus increased significantly (P＜0.01). Conclusion Electro- acupuncture may increase the expression of NMDAR1 mRNA, make full activation of NMDAR, enhance LTP, to improve the learning-memory capacity of rats with AD.关键词
电针/老年痴呆/海马/N-甲基-D-天冬氨酸受体1 mRNA/大鼠Key words
electro-acupuncture；Alzheimer's disease；hippocampus；NMDAR1 mRNA；rats分类
医药卫生引用本文复制引用
沈峰,孙国杰,杜艳军,周华,马骏,孔立红..电针对老年痴呆大鼠海马 N-甲基-D-天冬氨酸受体1mRNA的影响[J].中国中医药信息杂志,2012,19(8):38-40,3.基金项目
国家自然科学基金(30772837) （30772837）
