电针对老年痴呆大鼠海马 N-甲基-D-天冬氨酸受体1mRNA的影响OACSCDCSTPCD
Effect of Electro-acupuncture on N-Methyl-D-aspartate Receptor 1 Messenger RNA in Hippocampus with Alzheimer's Disease
目的 观察电针对老年痴呆(AD)模型大鼠海马N-甲基-D-天冬氨酸受体1(NMDAR1)mRNA的影响,探讨其作用机制.方法 将SD大鼠按随机数字表分为4组,即正常组、假手术组、模型组、电针组,每组10只.采用双侧海马一次性注射聚集态Aβ25-35制备AD大鼠模型,电针组选取双侧"肾俞"、"内关"和"大椎",接G6805-Ⅱ型电针治疗仪,选用2 Hz连续波,强度为1 mA,通电20 min,每日1次,每周6次,共治疗2周.采用原位杂交法检测各组大…查看全部>>
Objective To observe the effect of electro-acupuncture on the expression of NMDAR1 mRNA in the hippocampus of rats with Alzheimer's disease (AD), and discuss the mechanism. Methods SD rats were randomly divided into 4 groups：the normal group, sham-operated group, model group, electro-acupuncture group. Bilateral hippocampus were injected condensed Aβ25-35 to make rat model of AD. Electro-acupuncture group were selected bilateral Shenshu points, bilateral Nei…查看全部>>
沈峰;孙国杰;杜艳军;周华;马骏;孔立红
湖北中医药大学针灸骨伤学院,湖北,武汉,430061湖北中医药大学针灸骨伤学院,湖北,武汉,430061湖北中医药大学针灸骨伤学院,湖北,武汉,430061湖北中医药大学针灸骨伤学院,湖北,武汉,430061湖北中医药大学针灸骨伤学院,湖北,武汉,430061湖北中医药大学针灸骨伤学院,湖北,武汉,430061
医药卫生
电针老年痴呆海马N-甲基-D-天冬氨酸受体1 mRNA大鼠
electro-acupuncture；Alzheimer's disease；hippocampus；NMDAR1 mRNA；rats
《中国中医药信息杂志》 2012 (8)
从Wnt信号转导探讨不同针灸预刺激对学习记忆功能障碍的作用机制
38-40,3
国家自然科学基金(30772837)
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