中华耳科学杂志2012，Vol.10Issue(2)：144-148,5.DOI:10.3969/j.issn.1672-2922.2012.02.002
7.0T磁共振成像观察耳后给药促进药物进入内耳的可行性
Feasibility study of inner ear drug delivery via post-auricular injection using 7.0 Tesla MRI
摘要
Abstract
Objective To investigate the feasibility of postauricular injection as a drug administration route in treating inner ear disorders. Methods Twelve albino guinea pigs were divided randomly into two groups to receive either a post-auricular or intravenous bolus of gadopentetate dimeglumine (Gd-DTPA). A 7.0 Tesla MRI system, specially designed for small animals, was used to observe the signal changes of gadolinium enhanced images of the right cochlea for forty-eight hours. The observation time paints included pre-administration, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24 and 48 h post-administration. The relative signal intensity in the right scala tympani of the basal turn was measured to evaluate indirectly the dynamic Gd uptake in the perilymph. The area under the signal-time curve was calculated and compared between the two administration routes. Results Post-auricularly treated guinea pigs revealed a higher area under the signal - time curve from pre-injection to the last time point (P < 0.05). Conclusions Post-auricular injection may be a potential and efficient route for inner ear drug delivery.关键词
内耳/外淋巴液/给药方式/磁共振成像Key words
Inner ear, Perilymph/ Drug administration routes/ Magnetic resonance imaging分类
医药卫生引用本文复制引用
李晶兢,余力生,夏睿,郜发宝,骆文龙,静媛媛..7.0T磁共振成像观察耳后给药促进药物进入内耳的可行性[J].中华耳科学杂志,2012,10(2):144-148,5.基金项目
国家自然科学基金(81070780),首都医学发展基金(20091015) （81070780）
