中华耳科学杂志2012，Vol.10Issue(2)：252-254,3.DOI:10.3969/j.issn.1672-2922.2012.02.027
耳聋基因芯片技术在耳聋病因诊断中的应用
Application of gene chip in determing deafness etiologies
摘要
Abstract
Objective To report application of gene chip in etiological diagnosis in patients with hearing loss. Methods Patients (n=26) with confirmed sensorineural hearing loss were identified to receive DNA microarray tests to determine the etiopathogenisis of their hearing loss. Results Positive rate was 40.00 % in the 10 cases of congenital deafness, 23.08% in the 13 cases of adult sensorineural deafness and in 66.67% in the 5 cases of sudden sensorineural deafness. Conclusion Testing of nine deafness gene mutation using the DNA microarray helps identify the etiology of deafness in patients with hearing loss and worth broad utilization in clinic.关键词
耳聋基因芯片/耳聋/病因诊断Key words
DNA diagnostic chip for hearing loss/ Deafness/ Etiological diagnosis分类
医药卫生引用本文复制引用
李琦,贾蓓,刘思平,黄晓莉,宋兰林..耳聋基因芯片技术在耳聋病因诊断中的应用[J].中华耳科学杂志,2012,10(2):252-254,3.基金项目
本研究获南方医院新技术、新业务基金资助 （）
