浙江医学2012，Vol.34Issue(13)：1117-1119,3.
血浆脑钠素筛查对糖尿病早期心肌病变的意义
Screening of early cardiomyopathy with plasma brain natriuretic peptide in diabetic patients with left ventricular diastolic dysfunction
摘要
Abstract
Objective To assess screening of early cardiomyopathy with plasma brain natriuretic peptide (BNP) in diabetic patients with left ventricular diastolic dysfunction (LVDD). Methods Left ventricular systolic and diastolic function was e-valuated by pulsed Doppler ultrasonography in diabetic patients. Plasma BNP levels were measured by immunofluorescence method in 70 diabetic patients with abnormal LVDD, 31 patients with normal LVDD and 30 healthy subjects. Results Compared to normal controls and diabetics with normal left ventricular diastolic function, plasma BNP levels were significantly elevated in LVDD group (P<0.01). BNP levels were negatively correlated with LVDD (P<0.05). The optimal cut-off BNP level to identify type 2 diabetes with LVDD was 10.05pg/ml. Conclusion Plasma BNP level can be used for screening of early cardiomyopathy in diabetic patients with left ventricular diastolic dysfunction, and patients with BNP ≥10.05 pg/ml are recommended to undergo pulsed Doppler ultrasound examination.关键词
糖尿病/利钠肽/脑/左心室舒张功能Key words
Diabetes/ Natriuretic peptide/ Brain/ Left ventricular diastolic dysfuntion引用本文复制引用
吴天凤,郑和昕,袁放,江缨,叶萌,周欢琴..血浆脑钠素筛查对糖尿病早期心肌病变的意义[J].浙江医学,2012,34(13):1117-1119,3.基金项目
浙江省老年重点学科招标项目(2007ZB012) （2007ZB012）
