浙江医学2012，Vol.34Issue(13)：1136-1139,4.
重度子宫内膜异位症伴不孕患者治疗方案的合理选择
Selection of therapeutic modalities for patients with severe endometriosis and infertility
马俊彦 1阮菲2
作者信息
- 1. 310006,杭州,浙江大学医学院附属妇产科医院女性生殖健康重点实验室
- 2. 310006,杭州,浙江大学医学院附属妇产科医院妇科
- 折叠
摘要
Abstract
Objective To select appropriate therapeutic modalities to improve the reproductive outcome and delay relapse in patients with severe endometriosis and infertility. Methods Clinical data of 81 patients with stage III -IV endometriosis and infertility were retrospectively reviewed. Among those patients, 4 were treated with conservative surgery alone (group A), 28 were treated with gonadotropin-releasing hormone agonist (GnRHa) for 3 to 6 months after a conservative surgery (group B) , 6 were treated with in vitro fertilization - embryo transfer (IVF-ET) after a conservative surgery (group C) , 8 treated with IVF-ET directly without surgery (group D) , 35 were treated with GnRHa for 3 to 6 months after a conservative surgery, then underwent IVF-ET (group E). The recurrence and pregnant outcomes were compared after a median follow-up of 48.2±3.8months. Results The pregnancy rate in D and E groups was significantly higher than that in A and B groups (P= 0.038.P = 0.02). The live birth rate of ovulation pregnancy in E group was higher than that in C and D groups (P= 0.048). The recurrence rate in E group was much lower than other groups (P<0.05) and the duration of recurrence in C and E groups was longer than that in A and B groups (P <0.05). Conclusion Surgery plays a limited role in improving reproductive outcome in patients with severe endometriosis and infertility, but GnRHa treatment with IVF-ET after conservative surgery can improve the pregnancy rate.关键词
子宫内膜异位症/不孕/GnRHa/辅助生育技术Key words
Endometriosis/ Infertility/ GnRHa/ IVF-ET引用本文复制引用
马俊彦,阮菲..重度子宫内膜异位症伴不孕患者治疗方案的合理选择[J].浙江医学,2012,34(13):1136-1139,4.
