肿瘤防治研究2012，Vol.39Issue(6)：683-686,4.DOI:10.3971/j.issn.1000-8578.2012.06.017
MMP-9和MMP-2基因多态性与原发性肝癌侵袭转移的关系
Correlation of MMP-9 and MMP-2 Gene SNPs with Hepatocellular Carcinoma Invasion and Metastasis
吴时胜 1邵立华 2李尚日 1张飞 1谢鸿 1张春秀 1刘桂平1
作者信息
- 1. 435002湖北黄石,黄石市第二医院消化内科
- 2. 武汉市第五医院消化内科
- 折叠
摘要
Abstract
Objectlve To investigate the association between MMP-9 and MMP-2 gene SNPs of promoter regions and both infiltration and metastasis in hepatocellular carcinoma. Methods PCR- restriction fragment length polymorphism(PCR-RFLP) technique was applied to detect MMP-2 and MMP-9 promoter SNPs in 28 patients with hepatocellular carcinoma(8 cases with metastasis) and 42 healthy people. Results The risk of early metastasisof MMP-9-1562TT genotype was increased up to 1. 25-fold(95%CI,3. 64 ~ 5. 69),compared with MMP-9-1562CC or CT genotype,and irrelevant to the age or gender of patients. The risk of liver cancer in population harboring MMP-9-1562TT and MMP-2-1306CC or CT genotypes was significantly higher than in those harboring MMP-9-1562TT,MMP-2-t306CC or TT alone. Conclusion MMP-2-1306T/C polymorphism alone is not a risk factor of primary liver cancer,although has syn-ergistic interactions with MMP-9-1562C/T genotype, MMP-2 and MMP-9 gene polymorphism are related to the infiltration and metastasis of primary liver cancer.关键词
原发性肝癌/MMP-2/MMP-9/基因多态性Key words
Hepatocellular carcinoma / Matrix metalloproteinases-9/ Matrix metalloproteinases-2/ Single nucleotide polymorphism
分类
医药卫生引用本文复制引用
吴时胜,邵立华,李尚日,张飞,谢鸿,张春秀,刘桂平..MMP-9和MMP-2基因多态性与原发性肝癌侵袭转移的关系[J].肿瘤防治研究,2012,39(6):683-686,4.
