肿瘤防治研究2012，Vol.39Issue(6)：687-690,4.DOI:10.3971/j.issn.1000-8578.2012.06.018
TEL/AML1、BCR/ABL、E2A/PBX1、MLL/AF4阳性儿童急性淋巴细胞白血病的临床特点及预后
Clinical Features and Prognosis in Childhood Acute Plymphoblastic Leukemia with TEL/AML1 ,BCR/ABL,E2A/PBX1 and MLL/AF4 Positive
王颖超 1殷楚云 1李涛 2冯磊 1王春美 1盛光耀1
作者信息
- 1. 450052郑州,郑州大学第一附属医院儿科
- 2. 450052郑州,郑州大学第一附属医院血液病研究所
- 折叠
摘要
Abstract
Objective To explore the expression and clinical significance of TEL/AMLl ,BCR/ABL,E2A/ PBX1 and MLL/AF4 fusion gene in childhood acute lymphoblastic leukemia(ALL). Methods Bone marrow samples were collected from 312 children with newly diagnosed ALL, and E2A/PBX1, BCR/ ABLpt90(e1a2)and p210(b2a3,b3a2) isoforms,TEL/AMLl and MLL/AF4 fusion gene were detected by RQ-PCR. Meanwhile, Clinico-biological characteristic, therapeutic response and outcome were retrospectively analyzed. Results (1) The fusion genes were positive in 120 ALL children. 72 cases(23. 1 %) expressed TEL/AML1,22 cases(7. 1%) expressed BCR-ABL( including 16 cases(5. 1 %) p190 and 6 ca-ses(1.9%) p210.!8 casesfS.8%) expressed E2A/PBX1 and S cases(2.6%) expressed MLL/AF4). (2) In TEL/AML1 positive children,the leukocyte count was(18. 02 ± 6. 45) × 109/L with a 100% complete remission(CR) rate and none relapsed during follow-up. In BCR/ABL positive children, the mean age was (9. 40 ± 3. 55) years old with 81,8% CR rate. 6 cases still expressed the fusion gene at the end of intensive treatment. 8 children relapsed and 8 children died during follow-up. In E2A/PBX1 positive children, all of them were given chemotherapy according to high risk standard. The CR rate was 88. 9%. Three cases expressed micro-content fusion gene at the end of intensive treatment. 2 cases relapsed during follow-up. In MLL/AF4 positive children, the leukocyte count was(41. 53 ± 9. 46) × 109/L. 2 cases still expressed the fusion gene at the end of intensive treatment,and both of them relapsed and died. Conclusioa Fusion genes are important indexes for risk stratification, MRD monitoring and prognosis estimation in children with ALL.关键词
急性白血病/儿童/融合基因/TEL/AML1/BCR/ABL/E2A/PBX1/MLL/AF4Key words
Acute Leukemia/Children/Fusion gene/TEL/AMLl /BCR/ABL/E2A/PBX1 /MLL/AF4
分类
医药卫生引用本文复制引用
王颖超,殷楚云,李涛,冯磊,王春美,盛光耀..TEL/AML1、BCR/ABL、E2A/PBX1、MLL/AF4阳性儿童急性淋巴细胞白血病的临床特点及预后[J].肿瘤防治研究,2012,39(6):687-690,4.
