肿瘤防治研究2012，Vol.39Issue(6)：691-693,3.DOI:10.3971/j.issn.1000-8578.2012.06.019
uPA基因启动子区低甲基化在鼻咽癌侵袭转移中的作用
Promoter Hepomethylation of uPA Gene Play a Role in Invasion and Metastasis of Nasopharyngeal Cancer
摘要
Abstract
Objective To explore the relationship between of the promoter hepomethylation of uPA gene and invasion and metastasis of nasopharyngeal cancer. Methods Methylation-specific polymerase chain reaction (PCR) and reverse transcription PCR techniques were used to determine the promoter methylation status and tnRNA expression of uPA gene in nasopharyngeal cancer and chronic inflammation tissue in pharynxnasalis. Results Hepotnethylation of uPA gene promoter was found in 51 of 58 nasopharyngeal cancer samples. Hepermethyla-tion of uPA gene promoter was found in the other seven nasopharyngeal cancer tissues. Hepermethylation of uPA gene promoter was found in all chronic inflammation tissue of pharynx nasalis. Over-expression of uPA mRNA was found in nasopharyngeal carcinoma tissues which promoter hepomethylation. Weak or no expression of uPA mRNA was found in nasopharyngeal carcinoma which promoter hepermethylation cance and chronic inflammation tissue in pharynx nasalis. Conclusion Over-expression of uPA gene is relate to promoter hepomethylation in nasopharyngeal cancer tissues. Promoter hepomethylation of uPA gene possiblely concerned with invasion and metastasis of nasopharyngeal cancer.关键词
尿激酶型纤溶酶原激活剂(uPA)/低甲基化/鼻咽癌Key words
Urokinase plasminogen activator(uPA) /Hypomethylation/ Nasopharyngeal cancer分类
医药卫生引用本文复制引用
张松,李烁,高春生..uPA基因启动子区低甲基化在鼻咽癌侵袭转移中的作用[J].肿瘤防治研究,2012,39(6):691-693,3.基金项目
教育部博士学科点专项科研基金(新教师基金)(20070487172) （新教师基金）
