肿瘤防治研究2012，Vol.39Issue(6)：710-712,3.DOI:10.3971/j.issn.1000-8578.2012.06.024
隔姜灸预防化疗所致恶心呕吐的对照实验
A Constructive Experimental Study on Prevention of Chemotherapy-induced Nausea and Vomiting by Ginger-partitioned Moxibustion on Acupoint of Zusanli
摘要
Abstract
Objective To research the prevention of ginger-partitioned moxibustion on Zusanli against chemotherapy- induced nausea and vomiting,and to explore the feasibility of traditional medicine to relieve the gastrointestinal toxicity of chemotherapy. Methods A prospective crossover comparison method was employed. Thirty cases with three cycles of chemotherapy were divided into three groups: moxibustion group,ondansetron group,and moxibustion + ondansetron group. And serum 5-HT levels were tested in the first day before chemotherapy,the first day and the ninth day after chemotherapy. Results The antiemetic response rate was 80.0% ,83. 3% and 93.3% respectively in three groups,without significant difference (P>0. 05). The serum 5-HT levels were not significantly different (P>0. 05) among the three groups before and after chemotherapy. However, in moxibustion group and moxibustion + ondansetron group,the serum 5-HT levels in the first day after chemotherapy were significantly higher than those in the first day before chemotherapy and the ninth day after chemotherapy (P<0. 05). In ondansetron group, the 5-HT levels in the first day after chemotherapy was significantly higher than those in the first day before chemotherapy (P<0. 05) .but similar to those in the ninth day (P>0. 05). Conclusion Moxibustion had different antiemetic mechanisms, compared to ondansetron, although the effect was similar. Moxibustion was a low-cost,little side effects,simple operation,especially combined with agents.关键词
化疗/恶心/呕吐/隔姜灸/足三里/5-HTKey words
ChemotherapysNausea/Vomiting/Ginger moxibustion/Zusanli/5-bydroxy tryptamine分类
医药卫生引用本文复制引用
徐璐,李春来,李凌..隔姜灸预防化疗所致恶心呕吐的对照实验[J].肿瘤防治研究,2012,39(6):710-712,3.基金项目
江西省卫生厅中医药科研基金资助项目(2007Z008) （2007Z008）
