肿瘤防治研究2012，Vol.39Issue(6)：725-727,3.DOI:10.3971/j.issn.1000-8578.2012.06.029
长春瑞滨联合顺铂治疗蒽环类和(或)紫杉类耐药转移性三阴性乳腺癌的疗效分析
Treatment of Vinorelbine Plus Cisplatin to Metastatic Triple-negative Breast Cancer with Anthracycline and(or) Taxane-resistance
何东宁 1哈敏文1
作者信息
- 1. 121000辽宁锦州,辽宁医学院附属第一医院肿瘤内科
- 折叠
摘要
Abstract
Objective To investigate the short-term efficacy and safety of vinorelbine plus cisplatin for an-thracyctine and (or) taxane-resistant metastatic triple-negative breast cancer. Methods Thirty patients with anthracycline and (or) taxane-resistant metastatic triple-negative breast cancer patients received vinorelbine and cisplatin regimen: vinorelbine 25 mg/m2, d1 . d8 ; cisplatin 25 mg/m2, d2 ~ d4. Treatments were repeated every 21 days and response rate was evaluated every two cycles. Results Complete remis-sion(CR),partial remission(PR) .stable disease(SD) and progressive disease(PD) were 1 case(3. 3%) .16 cases(53. 3%). 10 cases (33. 3%) and 3 cases (10. 0%) , respectively. Objective response rate was 56. 7%. The main adverse reactions were bone marrow suppression and gastrointestinal reactions. Conclusion Combination of vinorelbine and cisplatin was an effective and well-tolerated rescue regimen in anthracycline and(or) taxane-resistant metastatic TNBC patients.关键词
三阴性乳腺癌/长春瑞滨/顺铂/蒽环类和(或)紫杉类耐药Key words
Triple-negative breast cancer/VinorelbinesCisplatinsAnthracycline and (or) taxane-resistant
分类
医药卫生引用本文复制引用
何东宁,哈敏文..长春瑞滨联合顺铂治疗蒽环类和(或)紫杉类耐药转移性三阴性乳腺癌的疗效分析[J].肿瘤防治研究,2012,39(6):725-727,3.
