中南民族大学学报：自然科学版2012，Vol.31Issue(2)：10-14,5.
β-环糊精衍生物流动相添加剂应用于HPCE中分离布洛芬
Separation of Ibuprofen in HPCE with β-Cyclodextrin Derivative
摘要
Abstract
Chiral separation of ibuprofen was investigated by bis- L -6-oxygen - （ -2-m-carboxyl phenylsulfonyl - succinic acid 1,4 - ester -4 -）-]-β-cyclodextrin （β-CD-B2 ） as chiral additive in high performance capillary electrophoresis （HPCE）. The effect of concentration and pH of borax buffer solution, concentration of chiral additive β-CD-B2 and separation vohage on the separation were discussed. The results indicated that the HPCE resolution （ RS ） under optimum condition was 4.26 in 8 min . Linear range of ibuprofen enantiomers＇ s separated front peaks is 0. 053 - 0. 942g/L, while later peak linear range is 0. 178 -0.942g/L. Thus ibuprofen and bupivacaine, two chiral drugs can be separated under the same condition best suited for ibuprofen.关键词
高效毛细管电泳/β-环糊精衍生物/流动相添加剂/手性分离/布洛芬Key words
HPCE/β-cyclodextrin derivative/mobile phase additive/chiral separation/ibuprofen分类
化学引用本文复制引用
沈静茹,朱财延,余学红,韦慧慰,邱思杨..β-环糊精衍生物流动相添加剂应用于HPCE中分离布洛芬[J].中南民族大学学报：自然科学版,2012,31(2):10-14,5.基金项目
湖北省自然科学基金资助项目 （）
