中药材2012，Vol.35Issue(4)：525-528,4.
全蝎蜈蚣对CIA大鼠外周血CD4+CD25+FoxP3+Treg细胞的调节
Regulation Effect of Scorpio and Scolopendra on CD4 + CD25 +FoxP3 +Treg Cell in Peripheral Blood from Rats with Collagen-Induced Arthritis (CIA)
摘要
Abstract
Objective:To study the regulation effect of Scorpio and Scolopendra on CD4+ CD25+ FoxP3+ Treg Cell in peripheral blood from rats with collagen-induced arthritis. Methods:Sixty female Wistar rats were randomly divided into 6 groups, normal control group, model control group, low-dose, middle-dose and high-dose Scorpio and Scolopendra group,and the type Ⅱ collagen group. Rats' arthritis was induced by collagen. The number of CD4+ CD25+ FoxP3+ Treg cell in peripheral blood was tested by flow cytometry, and the level of IL-2 in serum was detected by enzyme linked immunosorbem assay. Results:Compared with the model groups,the levels of CD4+ CD25+ Treg cell and CD4+ CD25+ FoxP3+ Treg cell were increased obviously in the high and low dose of Scorpio and Scolopendra groups (P <0.05 or P <0.01), while the level of IL-2 in serum was decreased remarkably in the middle and low dose of Scorpio and Scokpendra groups ( P < 0.05 or P < 0.01). Conclusion: It is realized that Scorpio and Scolopendra effectively treat RA by regulating the level of CD4+ CD25+ FoxP3+ Treg cell to restore immunological tolerance.关键词
全蝎/蜈蚣/类风湿性关节炎/调节性T细胞Key words
Scorpio/ Scolopendra/ Rheumatoid arthritis/ Regulatory T cells分类
医药卫生引用本文复制引用
刘端勇,赵海梅,黄小英,左志琴,王艳辉,程绍民..全蝎蜈蚣对CIA大鼠外周血CD4+CD25+FoxP3+Treg细胞的调节[J].中药材,2012,35(4):525-528,4.基金项目
国家自然科学基金项目(30860377) （30860377）
江西省自然科学基金项目(2009GZY0118) （2009GZY0118）
江西省卫生厅科技计划(20092052) （20092052）
