癌变·畸变·突变2012，Vol.24Issue(4)：245-248,252,5.DOI:10.3969/j.issn.1004-616x.2012.04.001
中国人群结直肠癌中PIK3CA基因突变分析
Analysis of PIK3CA gene mutations in Chinese colorectal cancer
摘要
Abstract
OBJECTIVE: PIK3CA gene encodes the p110 a catalytic subunit of PI3K, and its oncogenic mutation is involved in tumorigenesis of colorectal cancer (CRC) through activating of PI3K pathway. Frequent mutation of the PIK3CA gene in Western CRC has been reported; however, the mutations status of the gene in Chinese CRC is unclear. The aim of the study was to evaluate the mutation status of PIK3CA gene in Chinese patients with CRC. METHODS: PIK3CA gene mutations were analyzed in 79 colorectal tumors by PCR and DNA sequencing. RESULTS: PIK3CA gene mutations were detected in 8.9% (7/79) of tumor samples 6.3% (5/79) and 2.5% (2/79) of point mutations were found in exon 9 and exon 20, respectively. The distribution pattern of PIK3CA gene mutations was consistent with previous studies. CONCLUSION: A subset of Chinese CRC with PIK3CA gene mutations was identified in the study. Oncogenic mutation of PIK3CA gene may contribute to PI3K pathway activation in the corresponding tumors.关键词
结直肠癌/PIK3CA/点突变/PI3K通路Key words
colorectal cancer/PIK3CA/point mutation/PI3K pathway分类
医药卫生引用本文复制引用
陈曦,贾雪梅,张彤彤,梁建伟,商利,霍艳秋,徐昕,周志祥,王明荣,张钰..中国人群结直肠癌中PIK3CA基因突变分析[J].癌变·畸变·突变,2012,24(4):245-248,252,5.基金项目
卫生行业公益专项(200902002-5),国家自然科学基金(30950013) （200902002-5）
