安徽农业科学2012，Vol.40Issue(23)：11707,11756,2.
富甘氨酸果蝇抗菌肽SK66对子宫颈癌细胞Hela增殖的研究
Study of the Glycine-rich Antibacterial Peptide of Drosophila SK66 on the Proliferation of Cervices Cancer Cells (Hela)
摘要
Abstract
A polypeptide SK66 ,a 66-amino acid peptide with N-Serine (S) and C-Lysine ( K) ,is a glycine-rich antibacterial peptide of Drosophila. SK66 could kill cervices cancer cells ( Hela). After treated by SK66 .most cervices cancer cells ( Hela) suspended for the destroyed anchorage-dependent characterization and died. Observed by MTT,SK66 could remarkably inhibit the proliferation of the cervices cancer cells ( Hela). Using patch clamp technique.it was found out that SK66 could form cationic channels in DRG cells. The mechanism might be to perforate the pell membrane and lead to protoplasm leak and cancer cells rupture and death.关键词
果蝇/富甘氨酸抗菌肽/膜片钳/细胞增殖/阳离子通道Key words
Drosophila/ Glysine-rich antibacterial peptides/ Patch clamp/ Cell proliferation/ Cationic channel分类
农业科技引用本文复制引用
冯志国,刘慧娟,李涛,陈正望..富甘氨酸果蝇抗菌肽SK66对子宫颈癌细胞Hela增殖的研究[J].安徽农业科学,2012,40(23):11707,11756,2.基金项目
国家自然科学基金项目(30370647) （30370647）
信阳师范学院和河南省青年骨干教师项目. （）
