安徽医科大学学报2012，Vol.47Issue(10)：1156-1160,5.
佐剂关节炎大鼠肺功能变化与Notch1、Notch2/Jagged1、Jagged2通路的相关性
Correlation between changes of pulmonary function and Notch1,Notch2/Jagged1,Jagged2 signaling pathway in adjuvant arthritis rats
摘要
Abstract
Objective To evaluate the correlation between decline of pulmonary function and Notch1, Notch2/Jag-ged1, Jagged2 signaling pathway in adjuvant arthritis rats( AA rats ). Methods 40 AA rats were randomly divided into normal group and model group. Rats in MC group were induced to AA model by intradermally injecting 0. 1 ml Freund's complete adjuvant into the right paw. After 30 days,paw edema volume, arthritis index,pulmonary function , histo-morphological changes of pulmonary were observed, and the expressions of Notchl, Notch2/Jagged1, Jag-ged2 by RT-PCR of AA rats were detected. Results Compared with NC group, paw edema volume, arthritis index in MC group significantly increased, while FVC, FEF50 , FEF75, PEF and the expressions of Notchl, Jagged1, Jag-ged2 in lungs significantly decreased ( P <0. 05 ,P <0. 01 ). The correlation analysis indicated that there were significant positive correlations between FVC and Jagged1, FEV1/FVC and Notch1, FEF50 and Jagged2; FEF75 was positively correlated with MAC and MDC respectively, while negatively correlated with Jaggedl ( P < 0. 05, P < 0. 01 ). Conclusion While arthritis occurs in A A rats, pulmonary function declines and significantly correlates with the expression of Notch receptor/ligand, suggesting that the deposition of immune complex in pulmonary following injection of CFA activates Notch signaling pathway, and results in further decline of pulmonary function by signaling cascades.关键词
佐剂关节炎/肺功能/Notch1~2/Jagged1~2Key words
adjuvant arthritis/ pulmonary function/ Notch1 ~ 2/ Jagged1 ~ 2分类
医药卫生引用本文复制引用
万磊,刘健,程园园,冯云霞,刘磊,黄传兵,汪元..佐剂关节炎大鼠肺功能变化与Notch1、Notch2/Jagged1、Jagged2通路的相关性[J].安徽医科大学学报,2012,47(10):1156-1160,5.基金项目
国家自然科学基金(编号:81173211) （编号:81173211）
国家中医药重点学科中医痹病学建设项目(编号:国中医药发[2009]30号) （编号:国中医药发[2009]30号）
安徽省科技厅科研计划项目(编号:09020304046) （编号:09020304046）
安徽省卫生厅中医药科研项目(编号:2009ZY05) （编号:2009ZY05）
安徽现代中医内科应用基础与开发研究省级实验室建设项目(编号:科条[2008]150号)安徽中医学院科技创新团队项目(编号:2010TD005) （编号:科条[2008]150号）
