安徽医科大学学报2012，Vol.47Issue(10)：1212-1214,3.
Graves病甲状腺功能亢进症131I治疗前后TGAb、TPOAb水平变化及与早发甲状腺功能减退症的关系
Clinical observation of TGAb and TPOAb levels in early hyperthyroidism before and after 131I therapy with Graves disease
李春燕 1董林 1李素梅 1方星星 1王菊梅 1荆春艳 1姜妍芳 1金晓毛 2任安 1陈超1
作者信息
- 1. 安徽医科大学附属省立医院内分泌科,合肥,230001
- 2. 安徽医科大学附属省立医院核医学科,合肥,230001
- 折叠
摘要
Abstract
Objective To study the value of TGAb and TPOAb in patients with Graves disease before and after 131I therapy, as well as the relationship with premeture hypothyroidism. Methods 81 patients were divided into positive group( group A, 46 ) and negative group ( group B, 35 ) according to TGAb and TPOAb levels before 131I treatment. Serum levels of TGAb and TPOAb, TSH, FT3, FT4 were measured before and six months after 131I therapy respectively. Results TGAb and TPOAb levels in group A revealed no significant difference before and after the treatment; The TGAb and TPOAb levels in group B were significantly higher after treatment than before ( P < 0. 01 ). The rates of early hypothyroidism were 47. 8% in group A, 22. 9% in group B respectively, and the rate of group A was higher than that of group B statistically ( P < 0. 05 ). The serum levels of TSH in hypothyroidism had positive correlation with the levels of TGAb and TPOAb( r = 0. 405 ,0. 378, P = 0. 026,0. 035 ) and the thyroid mass ( r = 0. 366, P = 0. 051 ). Conclusion The probability of early hypothyroidism is ralated to the levels of TGAb and TPOAb before 131I treatment, for patients with small thyroid glands especially. However, the mechanism of serum TGAb and TPOAb levels increased after 131I therapy needs further clinical observation.关键词
Graves病/131I治疗/TGAb/TPOAb/甲状腺功能减退症Key words
Graves disease/131I therapy/ TGAb/ TPOAb/ hypothyroidism分类
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李春燕,董林,李素梅,方星星,王菊梅,荆春艳,姜妍芳,金晓毛,任安,陈超..Graves病甲状腺功能亢进症131I治疗前后TGAb、TPOAb水平变化及与早发甲状腺功能减退症的关系[J].安徽医科大学学报,2012,47(10):1212-1214,3.
