安徽医科大学学报2012，Vol.47Issue(10)：1218-1221,4.
乙型肝炎肝硬化并发原发性肝癌的危险因素评估
Risk factors for hepatocellular carcinoma in patients with liver cirrhosis
陈萍 1李江 1苏菲 1李家斌 1程君1
作者信息
- 1. 安徽医科大学第一附属医院感染病科,合肥,230022
- 折叠
摘要
Abstract
Objective To evaluate the risk factors hepatocellular carcinoma ( HCC ) due to LC, in order to provid prevention references. Methods 3 : 1 case-control study was analysed the related-risks for HCC retrospectiverly. 330 HCC patients in observation group and 110 patients with course of the LC disease for over 10 years in the control group were both admitted to the first affiliated hospital of Anhui medical university in the same period. Results By univariate analysis and muiltiple logistic regression analysis, five factors were involved in the mode of muiltiple logistic regression analysis, including long-term smoking history, diabetes mellitus( DM ), anti-HB V therapy, hepatitis B virus ( HBV ) replication, HBeAg-negative accompanied by HBV replication, which had close relations with hepatocarcinogenesis. The odds ratio ( OR ) values were 2. 495 ( 1. 293 ~ 4. 816 ), 18. 167 ( 2. 261 ~ 145. 95 ), 0. 185( 0. 100 ~ 0. 343 ), 1. 184( 1. 072 ~ 1. 308 ), 2. 916( 2. 041 ~ 4. 165 ), respectively. Conclusion Patients with LC accompanied with HBV DNA positive, especially HBsAg, anti-HBe, anti-HBc accompanying with HBV DNA positive, long-term smoking history as well as diabetes are populations of primary hepatic carcinoma at higher risk, while the risk can be reduced by antiviral therapy.关键词
乙型肝炎肝硬化/肝癌/危险因素Key words
hepatitis B cirrhosis/ hepatocellar carcinoma/ risk factors分类
医药卫生引用本文复制引用
陈萍,李江,苏菲,李家斌,程君..乙型肝炎肝硬化并发原发性肝癌的危险因素评估[J].安徽医科大学学报,2012,47(10):1218-1221,4.
