成都中医药大学学报2012，Vol.35Issue(2)：21-24,91,5.
电针调节VBI家兔耳蜗核γ-氨基丁酸B受体表达和对耳蜗的保护
Elecrtoacupuncture Protect Cochlea by Adjusting Expression of Gamma-aminobutyric Acid B Receptor in Cochlear Nucleus in Rabbit with VBI
摘要
Abstract
Objective; To investigate electroacupunctrue (EA) adjusting the expression of the efferent neurotransmitter of gamma-aminobutyric acid B receptor ( GABABR) to affect the configuration and function of the organ of Corti in cochlea by comparing the effects of flunarizine hydrochloride on vertebrobasilar insufficiency (VBI) rabbit models. Methods; Injected with sclerosant -775 injection into the solt tissue on the left side of cervical vertebral transverse processes of rabbits to set up cervical spondyloric vertebral arteriopathy model with VBL The control group was injected with saline. Results; From the 6th weeks after injecting , acupuncture points at bilateral "Fengchi (GB20)" "Tingkong (SI 19)" and "Waikuan (SJ5)" were administered to the rabbits in the EA group , and the flunarizine group was given flunarizine hydrochloride by affusing stomach. After 2 weeks, the thresholds of cochlear nerve compound action potential (CAP) in the model group, EA group and flunarizine group were higher than those in the control group (P < 0.001), and the EA group and flunarizine group were lower than those in the model group (P< 0.001) . The thresholds of CAP induced by high frequency tone burst in the EA group and flunarizine group were higher than those induced by low frequency (P <0. 05) . The integral light density of GABABR positive reactant in the model group was significantly lower than that in the control group (P<0.001) , and those in the EA group and flunarizine group were evidently higher than that in the model group (P<0.01), and there was no difference among the three groups (P>0.05) . The number of survived hair cells in the model group, EA group and flunarizine group were remarkably less than that in the control group (P<0.001), and those in the EA group and flunarizine group were evidently more than that in the model group (P <0.001) . Conclusion: It was suggested that EA could increase the expression of B receptor for efferent GABA in auditory nerve system to protect the configuration of the cochlea and improve auditory function. The effects of EA are superior to flunarizine.关键词
椎-基底动脉供血不足/电针/γ-氨基丁酸/耳蜗/听觉Key words
Vertebrobasilar insufficiency/ electroacupunctrue/ gamma- aminobutyric acid/ cochlea/ hearing分类
医药卫生引用本文复制引用
郑重,郑博,宋开源..电针调节VBI家兔耳蜗核γ-氨基丁酸B受体表达和对耳蜗的保护[J].成都中医药大学学报,2012,35(2):21-24,91,5.基金项目
四川省教育厅自然科学基金资助项目(No.01LC11). （No.01LC11）
