成都中医药大学学报2012，Vol.35Issue(2)：27-30,4.
凋膜止崩方对无排卵功血大鼠增生子宫内膜中Bcl-2和Bax蛋白表达的影响
The Influence of Diao-mo-zhi-beng Prescription on Expression of Bcl-2 and Bax in Hyperplastic Endometrium of Rats
摘要
Abstract
Objective: To explore the modification of Bcl-2 and Bax before and after targeting interventions of Diao-mo-zhi-beng Prescription and the expression of protein in the endometrium hyperplasia of rat uterine tissue. Methods: Healthy adult female SD rate were randomly divided into 40, the control group ( A ) , model group ( B ), large dose of Diao-mo-zhi-beng prescription ( C ) , small dose of Diao-mo-zhi-beng prescription ( D ) , castrated rat combine estrogen load modeling success of intrauterine injection of medicine, Hie protein expression levels of Bcl-2 and bax were checked by Western-blot Results: In preoestrus, the expression of Bcl-2 in group A is lower and the expression of Bcl-2 in group B is higher. For expression of Bcl-2, group A has significant difference with group B (P<0.05) , and group B has significant difference with group C and group D, respectively (P<0.05) . And In preoestrus, the expression of Bax in group A is the higher and the expression of Bax in group B is the lower. For expression of Bax, group A has significant difference with group B (P <0.05), and group B has significant difference with group D (P<0. 05) . The expression of Bcl-2 has negative correlation with the expression of Bax in both group A and group B. Conclusion: The diaomozhipen prescription can dispel the extreme hyperpbistic endometrium of rats, and weaken the expression of Bcl-2 while enhance the expression of Bax. Moreover, the apoptosis of endometrium cell is accelerated.关键词
凋膜止崩方/子宫内膜增生症/Bcl-2/BaxKey words
Diao-mo-zhi-beng Prescription/ hyperplastic endometrium/ Bcl-2 / Bax分类
医药卫生引用本文复制引用
贺丰杰,李小宁,周燕..凋膜止崩方对无排卵功血大鼠增生子宫内膜中Bcl-2和Bax蛋白表达的影响[J].成都中医药大学学报,2012,35(2):27-30,4.基金项目
国家自然科学基金资助项目(No.30873354) （No.30873354）
陕西省"13115"科技创新工程重大科技专项计划项目(编号:2008ZDKG-81) （编号:2008ZDKG-81）
