南方医科大学学报2012，Vol.32Issue(7)：1008-1011,4.DOI:10.3969/j.issn.1673-4254.2012.07.023
巨细胞病毒感染对重型β-地中海贫血儿童异基因造血干细胞移植后早期T细胞亚群的影响
Impact of cytomegalovirus infections on T lymphocyte subsets in children with β-thalassemia major early after allogeneic hematopoietic stem cell transplantation
摘要
Abstract
Objective To investigate the effect of human cytomegalovirus (HCMV) infection on T lymphocyte subsets in children with β-thalassemia major (TM) during the initial 6 months after allogeneic hematopoietic stem cell transplantation (Allo-HSCT). Methods From January, 2010 to January, 2011, 35 children with TM underwent Allo-HSCT. Peripheral blood samples were obtained from the children 6 month after the transplantation to examine the changes of T lymphocytes subsets in relation to HCMV seroposirivity. Results Thirteen children were found seropositive and 22 were seronegative for HCMV. The HCMV-seropositive children had a higher CD8' cell percentage but a lower CD4' cell percentage than those without HCMV infection. Compared with those seronegative for HCMV, the children with HCMV seropositivity showed increased percentages of CD8+ cells and CD8+CD28- cells with a decreased percentage of CD8+CD28+ cells. A positive linear correlation was found between the percentages of CD8+ CD28- cells and CD8+ cells. Conclusion HCMV infection can lead to the accumulation of CD8+CD28 cells to cause increased CD8+ T cells in the peripheral Wood in TM children after Allo-HSCT. The percentages of CD8-CD28- cells has a positive linear correlation to that of CD8+ cells.关键词
巨细胞病毒/β-地中海贫血/儿童/造血干细胞移植/T细胞亚群Key words
cytomegalovirus/ β-thalassemia major/ children/ hematopoietic stem cell transplantation/ T lymphocyte subsets分类
医药卫生引用本文复制引用
王彦华,吴学东,冯晓勤,何岳林,裴夫瑜,李春富..巨细胞病毒感染对重型β-地中海贫血儿童异基因造血干细胞移植后早期T细胞亚群的影响[J].南方医科大学学报,2012,32(7):1008-1011,4.基金项目
广东省科技计划项目(2011B031800280) （2011B031800280）
