氢气对急性肺损伤大鼠肺组织p38MAPK活化的影响OA北大核心CSCDCSTPCD
Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide-induced acute lung injury
目的 探讨氢气对脂多糖(LPS)诱导急性肺损伤大鼠的肺保护作用及其可能的分子生物学机制.方法 采用腹腔注射LPS法建立大鼠急性肺损伤模型.32只雄性SD大鼠(体质量200～250g)随机分为4组(n=8):生理盐水组(SA组)、氢气吸入组(SH组)、急性肺损伤组(LA组)和急性肺损伤+氢气吸入组(LH组),氢气治疗为腹腔注射生理盐水或LPS后持续吸入混有低浓度氢气(2％)的空气6h,用Western blot技术检测肺组织中p38MAPK的表达,…查看全部>>
Objective To investigate the effect of hydrogen inhalation on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the underlying molecular mechanisms. Method Thirty-two male SD rats were randomly divided into 4 groups (n= 8), namely the normal saline group (SA), saline with 2% hydrogen gas inhalation group (SH group), ALI group, and ALI with hydrogen inhalation group (LH group). In the two ALI groups, ALI was induced by intraperitoneal injection of …查看全部>>
梁灿鑫;刘新伟;刘玲;何东伟
重庆医科大学附属第一医院麻醉科,重庆400016重庆医科大学附属第一医院麻醉科,重庆400016重庆医科大学附属第一医院麻醉科,重庆400016重庆医科大学附属第一医院麻醉科,重庆400016
医药卫生
氢气急性肺损伤肿瘤坏死因子-αp38MAPK
hydrogen acute lung injury tumor necrosis factor-α p38MAPK
《南方医科大学学报》 2012 (8)
1211-1213,1217,4
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