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Strategies for targeting the DNA damage response for cancer therapeutics

Dan Zhang Hai-Bo Wang Kathryn L. Brinkman Su-Xia Han Bo Xu

癌症（英文版）2012，Vol.31Issue(8)：359-363,5.

癌症（英文版）2012，Vol.31Issue(8)：359-363,5.DOI:10.5732/cjc.012.10087

Strategies for targeting the DNA damage response for cancer therapeutics

Dan Zhang ¹Hai-Bo Wang ²Kathryn L. Brinkman ³Su-Xia Han ³Bo Xu¹

作者信息

1. Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical School, Xi'an, Shaanxi 710061, P. R. China
2. Department of Radiation Oncology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
3. Department of Radiation Oncology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
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摘要

Abstract

The DNA damage response is critical for cells to maintain genome stability and survival.In this review,we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization.In addition,we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

关键词

DNA damage response/ DNA repair/ synthetic lethality/ PARP inhibitors

Key words

DNA damage response/ DNA repair/ synthetic lethality/ PARP inhibitors

引用本文复制引用

Dan Zhang,Hai-Bo Wang,Kathryn L. Brinkman,Su-Xia Han,Bo Xu..Strategies for targeting the DNA damage response for cancer therapeutics[J].癌症（英文版）,2012,31(8):359-363,5.

基金项目

This work was supported in part by grants from the National Institutes of Health,USA (No.R01CA133093 and R01ES016354) and the National Natural Science Foundation of China (No.81001027). （No.R01CA133093 and R01ES016354）

癌症（英文版）

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ISSN：1000-467X

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