福建农业学报2012，Vol.27Issue(5)：461-464,4.
新型鸭呼肠孤病毒病灭活疫苗的制备及免疫原性分析
Preparation and the Efficacy Evaluation of an Oil-emulsion Inactivated Vaccine Against Novel Duck Reovirus Disease
摘要
Abstract
Novel Duck Reovirus (NDRV) was the pathogen of duck Hetnorrhagic-necrotic hepatitis, which was an epizootic disease of ducklings, has been prevailed in China since 2005. In order to control the disease, one oil-emulsion inactivated vaccine had been developed by NDRV JM85 and the potential protective efficacy was assessed. The study indicated that this vaccine could induce strong immune responses after secondary immunization of sheldrake and the titers of neutralizing antibodies reach the peak at 28d post-immunization. 84d post-immunization, the neutralizing antibodies still maintain at a high level. Baby Muscovy ducks born from mothers vaccinated with the oil-emulsion vaccine were protected successfully against NDRV infection, during the first week of life when the risk of this disease was highest. These results showed that the vaccine had a good prospect for against novel duck reovirus disease.关键词
新型鸭呼肠孤病毒/鸭出血性坏死性肝炎/灭活疫苗/免疫原性分析Key words
Novel Duck Reovirus/ duck Hemorrhagic-necrotic hepatitis/ oil-emulsion inactivated vaccine/ efficacy evaluation分类
农业科技引用本文复制引用
陈仕龙,李兆龙,林锋强,王劭,程晓霞,朱小丽,陈少莺..新型鸭呼肠孤病毒病灭活疫苗的制备及免疫原性分析[J].福建农业学报,2012,27(5):461-464,4.基金项目
国家“863”计划项目(2011AA10A209) （2011AA10A209）
国家自然科学基金项目(31172334) （31172334）
福建省科技计划项目——省属公益类科研院所基本科研专项(2010R1025-5) （2010R1025-5）
