分析测试学报2012，Vol.31Issue(7)：779-784,6.DOI:10.3969/j.issn.1004-4957.2012.07.004
气球中N-亚硝胺及其前体物迁移量的测定与NDMA的儿童致癌暴露风险分析
Determination of Migration Levels of N-nitrosamines and N-nitrosatable Substances in Balloons and Carcinogenic Risk Exposure Level of NDMA in Balloon to Children
摘要
Abstract
A method for the determination of migration levels of 7 N-nitrosamines and N-nitrosatable substances was developed using Sep - Pak AC2 connected to Dry cartridges and gas chromatography -tandem mass spectrometry. Its analytical tolerances for N-nitrosamines and N-nitrosatable substances in balloon were 1. 25 p.g/kg and 5. 00 μLg/kg, respectively. The average recoveries of 7 N-nitrosamines at a spiked concentration of 2. 5 ^.g/kg ranged from 85% to 103% with RSDs(n =3) not more than 4. 6% . N-nitrosodimethylamine( NDMA) and N-nitrosodiethylamine( NDEA) and their precursors were the most frequently nitrosamines and nitrosatable substances found in balloon samples, while N-nitro8omorpholine ( NMOR), N-nitrosopiperidine ( NPIP) and N-nitrosodipropylamine ( ND-PA) and their precursors were not found in all balloon samples. The total migration values for 7 N-nitrosamines and N-nilrosatable substances in balloon samples were in the range of 0. 036 -0. 964 mg/ kg and 0. 259 -8. 436 mg/kg, respectively. The risk exposure level of NDMA via oral intake from each balloon to children aged from 6 months to 4 years was grouped in the class of 0. 010 mg/kg to 0. 030 mg/kg body weight, which would bring high carcinogenic risk to children potentially.关键词
气球/N-亚硝胺/前体物/气相色谱-串联质潜/致癌暴露风险Key words
balloon/ N-nitrosamine/ N-nitrosatable substances/ gas chromatography - tandem mass spectrometry/ carcinogenic risk exposure分类
化学化工引用本文复制引用
幸苑娜,王欣,陈泽勇,林浩学..气球中N-亚硝胺及其前体物迁移量的测定与NDMA的儿童致癌暴露风险分析[J].分析测试学报,2012,31(7):779-784,6.基金项目
国家质检总局科技计划项目(2011QK333) （2011QK333）
