分析测试学报2012，Vol.31Issue(7)：881-890,10.DOI:10.3969/j.issn.1004-4957.2012.07.023
键合型多糖类手性固定相的研究进展
Development Progress of Immobilized Chiral Stationary Phases Based on Polysaccharide Derivatives
摘要
Abstract
With their high chiral recognition to a broad range of chiral compounds, polysaccharide derivatives-based chiral stationary phases (CSPs) have been regarded as the most powerful CSPs in the direct resolution of enantiomers by HPLC. Since there are no chemical linkages between the polysaccharide derivatives and the supports, the coating - type CSPs exhibit some disadvantages such like poor solvent durability and rather limited mobile phase selection. With broadened mobile phase selection and improved stability, immobilizing-type polysaccharide-based CSPs overcome the disadvantages of the coated ones, and have become the hot topics in chiral separation in recent years. In this paper, five immobilization methods of the polysaccharide-based CSPs, including the bifunctional reagent method, chemical bonding of the amylose derivative via an activated chain end, radical polymerization, photoirradiation and intermolecular polycondensation, were introduced and compared, Furthermore, the further developments of those CSPs are prospected.关键词
多糖衍生物/手性固定相/键合/研究进展/综述Key words
polysaccharide derivatives/ chiral stationary phases/ immobilization/ development progress / review分类
化学化工引用本文复制引用
金召磊,汪一波,高建荣,潘富友,唐守万..键合型多糖类手性固定相的研究进展[J].分析测试学报,2012,31(7):881-890,10.基金项目
国家自然科学基金青年科学基金资助项目(20905057) （20905057）
