广东医学2012，Vol.33Issue(17)：2535-2538,4.
基础研究丹参酸提液对高脂大鼠骨量的影响
The effects of acid extract of salvia miltiorrhiza Bge on bone mass of high-lipid rats
摘要
Abstract
Objective To study the effects of acid extract of Salvia miltiorrhiza Bge ( SMB ) on the prevention of bone mass loss in tibia and vertebrae in high - fat - induced osteopenia rats. Methods Thirty 3 - month - old male Spra-gue - Dawley ( SD ) rats were randomly divided into NS group, high - fat emulsion ( HFE ) group, and SMB group. High fat emulsion lavage was given to the rats in HFE and SMB groups for construction of high - fat rat model, while stimulatory SMB extract was given to rats in SMB group. The subjects were sacrificed at 16th week for assessment of serum TC, TG, and HDL-C. PTM, LVB and Tx sections were collected for histomorphometric analysis. Results Compared with the HFE group, there were significant increase of serum HDL-C, % Tb. Ar, Tb. N and % Ob. S. Pm, while significant reduction in Tb. Sp, % Oc. S. Pm and Oc. N/mm were also revealed in SMB group ( P <0. 05 ). Meanwhile, there was significant increase of % Ct. Ar with reduction of % Ma. Ar in Tx of SMB group ( P < 0. 05 ); so were the increase of % Tb. Ar and Tb. Th and reduction of Tb. Sp in LVB ( P <0. 05 ). Conclusion SMB can effectively reverse the long - term high -fat diet - induced bone loss in rats.关键词
高脂乳剂/丹参酸提液/骨质疏松/骨组织形态计量学/大鼠Key words
high - fat emulsion/ acid extract of danshen/ osteoporosis/ bone histomorphometry/ rats引用本文复制引用
张新乐,吴铁,崔燎,许碧莲,邹丽宜,刘钰瑜,陈文双..基础研究丹参酸提液对高脂大鼠骨量的影响[J].广东医学,2012,33(17):2535-2538,4.基金项目
2011年广东省第一批科学事业费计划项目(编号:2011B031800248) （编号:2011B031800248）
