广东医学2012，Vol.33Issue(18)：2711-2714,4.
复方血栓通胶囊对糖尿病肾病大鼠的作用
The effects of Compound Xueshuantong Capsule on diabetic nephropathy
摘要
Abstract
Objective To investigate the effects of Compound Xueshuantong Capsule ( XST ) on diabetic ne-phropathy in rats. Methods Hyperglycemia ( fasting bood glucose > 16. 7 mmol/L ) was induced in 28 male Sprague Dawley ( SD ) rats by peritoneal injection of streptozotocin ( STZ, 50 mg/kg). The subjects were randomly divided into four groups: diabetic nephropathy group ( DN, treated with vehicle ), Irbesartan group [ IB, 20 mg/( kg · d ) ], low - dosage XST group [ LX, 900 mg/( kg · d ) ] and high - dosage XST group [ HX, 1 800 mg/( kg · d ) ]. Seven healthy SD rats were included as control group ( NC ). After a 12 -week intervention, urine protein was measured, while the pathological evaluation of kidney was carried out with HE, Masson and PAS stain and electron microscopy. Results The urinary albumins were significantly reduced in Group IB, LX and HX than that in DN group, without significant affection on either blood glucose or weight. Irbesartan and XST ameliorated the pathological injury of hyperglycemia on glomerular basement membrane, podocytes, mesangial cells according to HE, Masson and PAS stain, and electron microscopy. There were no significant difference between low - dosage XST and high - dosage XST group. Conclusion XST reduces urine protein and ameliorates renal injury in rats with diabetic nephropathy.关键词
糖尿病肾病/复方血栓通胶囊/足细胞/系膜细胞/基底膜Key words
diabetic nephropathy/ Compound Xueshuantong Capsule/ podocyte/ mesangial cell/ glomerular basement membrane引用本文复制引用
严晋华,朱延华,夏旋,徐芬,张雷,赵一,梁华,翁建平..复方血栓通胶囊对糖尿病肾病大鼠的作用[J].广东医学,2012,33(18):2711-2714,4.基金项目
"中央高校基本科研业务费专项资金"-2009年中山大学青年教师培育项目,广东省医学科研基金资助项目(编号:B2010096),广东众生药业横向课题"复方血栓通胶囊对糖尿病肾病的干预研究初探" （编号:B2010096）
