摘要
Abstract
Objective To explore the clinical significance of detection of cellular immunity and interleukin ( IL-1,IL-6,and TNF-α ) in children with bronchial asthma attack.Methods T cell subsets were detected by flow cytometry in 25 children with bronchial asthma in attack phase,23 in remission phase,and 20 healthy children,so were serum levels of IL-6,IL-8 and TNF-α by ELISA.Results Levels of IL-6,IL-8,and TNF-α were higher in children in attack phase than in those in remission phase and the healthy controls.These cytokines were higher in patients in remission phase than in the controls.CD3+,CD4+,CD4+/CD8+,and CD (16+56)+ decreased,while CD8+ increased.IL-6,IL8,and TNF-α were negatively related with CD3+,CD4+,CD4+/CD8+,and CD（ 16+56)+,but positively correlated with CD8+.Conclusions Dynamic detection of levels of IL-6,IL-8,and TNF-α and observation of changes in T cell subsets can reflect the inflammatory state of the airway in children with bronchial asthma,assess disease course correctly,and instruct proper uses of medications.关键词
支气管哮喘/T细胞亚群/细胞因子Key words
Bronchial asthma/T cell subsets/Cytokine
