国际医药卫生导报2012，Vol.18Issue(14)：1999-2003,5.DOI:10.3760/cma.j.issn.1007-1245.2012.14.005
pH敏感型壳聚糖-地塞米松纳米粒的制备及体外特性
Synthesis, characterization and evaluation of pH sensitive chitosan-dexamethasone prodrug in vitro
摘要
Abstract
[Objective]To synthesise the prodrug of chitosan-dexamethasone with pH sensitive release property.[Methods]The chitosan-dexamethasone prodrug was prepared by covalently linking via hydrazone bonds,and the structure of the prodrug was verified by 1H-NMR.The nanoprodrug was prepared by dialyse method,and the size and morphology were observed by dynamic light scattering and transmission electron microscope.The drug release in different pH of the prodrug was evaluated.[Results]The prodrug was synthesized and confirmed as expected.The size of the prodrug nanoparticle was about 100 ～ 250 nm,and the prodrug realeased faster in pH 5.8 than in pH 7.4 PBS solution.Conclsion The pH sensitve chitosan-dexamethasone prodrug is synthesized successfully,which has potential application in the rheumatoid arthritis treatment.关键词
壳聚糖/地塞米松/前药/pH敏感/纳米粒子Key words
Chitosan/Dexamethasone/Prodrug/pH sensitve/Nanopartical引用本文复制引用
冯荣洁,陈广斌,许碧莲..pH敏感型壳聚糖-地塞米松纳米粒的制备及体外特性[J].国际医药卫生导报,2012,18(14):1999-2003,5.基金项目
深圳市科技计划立项资助项目(201103253) （201103253）
