国际医药卫生导报2012，Vol.18Issue(14)：2033-2036,4.DOI:10.3760/cma.j.issn.1007-1245.2012.14.019
芹菜素改善肥胖型2型糖尿病小鼠胰岛素抵抗的实验研究
Experiment research of Apigenin improving insulin resistance in obesity type 2 diabetes mice
辜学敏 1吴华振 2韩坚 3陆彦4
作者信息
- 1. 510010 广州,广东省妇幼保健院
- 2. 510080广州,广东省人[医院
- 3. 510006 广州中医药大学
- 4. 510440广州,广东省生物制品与药物研究所
- 折叠
摘要
Abstract
[Objective]To explore the effects of flavonoids chemical Apigenin to the glucose,lipids and insulin resistance in the obesity type 2 diabetes mice-db/db mice.[Methods]12 dh/db mice were divided into two groups:the normal chow group(6 mice)and the Apigenin group(6 mice).The mice were given normal chow and Apigenin(200 mg/kg per mouse) by gastric gavage,additionally the db/db standard control C57BL/KsJ mice were chosen as the normal control group and given the normal chow add the saline by gastric gavage once a day.After 12 weeks of Apigenin intervention,the variation of body weight,fasting blood glucose,lipids levels,insulin level and the insulin sensitivity were detected,additionally,the visceral fat tissue was studied by H&E stain.[Results]After 12 weeks of Apigenin intervention,the body weight,the blood glucose level,the lipids level and the insulin level were significantly decreased in db/db mice,and the insulin sensitivity was significantly improved.In H&E study,we found the size of the adipocytes from the visceral fat tissue was smaller than that of the db/db control group(P ＜ 0.05).[Conclusion]Apigenin can prevent the mice insulin resistance,lower the blood glucose and prevent the weight gain in db/db mice.关键词
芹菜素/db/db小鼠/胰岛素抵抗/血糖/胰岛素敏感性Key words
Apigenin/Dh/db mice/Insulin resistance/Blood glucose level/Insulin sensitivity引用本文复制引用
辜学敏,吴华振,韩坚,陆彦..芹菜素改善肥胖型2型糖尿病小鼠胰岛素抵抗的实验研究[J].国际医药卫生导报,2012,18(14):2033-2036,4.
