国际医药卫生导报2012，Vol.18Issue(15)：2260-2263,4.DOI:10.3760/cma.j.issn.1007-1245.2012.15.053
神经节苷脂治疗手足口病并神经系统损害的临床疗效观察
Ganglioside for hand, foot and mouth disease complicated with central nervous system damage
邓文 1黄冬平 1唐远平 1黄苑铭 1王波1
作者信息
- 1. 510010 广州,广东省妇幼保健院儿科
- 折叠
摘要
Abstract
Objective To explore the efficacy of Ganglioside for hand, foot and mouth disease ( HFMD )complicated with central nervous system damage in pediatric patients.Methods 140 pediatric patients with HFMD complicated with central nervous system damage who were hospitalized into our hospital from Feb.2009 to Feb.2011 were randomly divided into treatment group and control group,70 for each group.All patients in both groups were treated with anti-virus drug and anti-infectious drug and received symptomatic treatment.Besides these,patents in treatment group were intravenously cured with 20 mg ganglioside for 10 days,while patients in control group were intravenously treated with citicoline,0.125-0.25 g/d.The electroencephalogram ( EEG ) and neuron-specific enolase ( NSE ),the duration of main symptoms and signs,time to recover,and hospital stay of the two groups were compared and analyzed.Results 65( 92.8％ ) patients in treatment group recovered in electroencephalogram( EEG )and neuron-specific enolase( NSE ).the duration of the main symptoms and signs,time to recover,and hospital stay were significantly shorter in treatment group than in control group ( P ＜ 0.05 ).Conclusions Ganglioside for hand,foot and mouth disease ( HFMD ) complicated with central nervous system damage is efficacious safe,and reliable and can reduce sequelae incindence.关键词
手足口病/神经系统/神经节苷脂/胞二磷胆碱Key words
Hand, foot and mouth disease/Central nervous system/Ganglioside/Citicoline引用本文复制引用
邓文,黄冬平,唐远平,黄苑铭,王波..神经节苷脂治疗手足口病并神经系统损害的临床疗效观察[J].国际医药卫生导报,2012,18(15):2260-2263,4.
