广东药学院学报2012，Vol.28Issue(4)：375-378,4.DOI:10.3969/j.issn.1006-8783.2012.04.005
光纤药物溶出仪在线考察和评价头孢克洛颗粒溶出度
Real-time online monitoring the dissolution of cefaclor granules by fiber-optic dissolution test system
摘要
Abstract
Objective To monitor the instantaneous dissolution of cefaclor granules by fiber-optic dissolution test system and evaluate its quality. Method The paddle method was used to determine the dissolution of cefaclor granules. The volume of four different menstruums were all 900 mL at 37 ℃ . The fiber optic probe of 2 mm was used with the rotate speed of 50 r · min-1. The detection wavelength was set at 264 nm and the data were collected every 30 seconds. The results were compared with the method stated in ChP. Results The detection results of the fiber-optic dissolution test system could meet the standard of ChP. The dissolution curves of different batches are identical, but there are slightly different between different menstruums. Conclusion Compared with the method stated in ChP, the fiber-optic dissolution test system is capable of monitoring the real dissolution process of drug, and it is better to provide ibe efficient way for the drug productive technology and inherent quality.关键词
光纤药物溶出仪/头孢克洛颗粒/实时在线监测系统/溶出度Key words
real-time online/ cefaclor granules/ fiber-optic dissolution test system/ dissolution分类
医药卫生引用本文复制引用
方继辉,陈英..光纤药物溶出仪在线考察和评价头孢克洛颗粒溶出度[J].广东药学院学报,2012,28(4):375-378,4.基金项目
广东省药品检验所科技创新基金资助项目(SN20091201) （SN20091201）
