广东药学院学报2012，Vol.28Issue(4)：423-426,4.DOI:10.3969/j.issn.1006-8783.2012.04.017
白藜芦醇抗喘活性及机制研究
Effect and mechanism of resveratrol on antiasthmatic activity
何冰 1王经韵 2郑宇翔 1徐浚超 1陈小夏1
作者信息
- 1. 广东药学院药科学院,广东广州510006
- 2. 广东省人民医院国家临床药物试验机构办公室,广东广州510080
- 折叠
摘要
Abstract
Objective To study the relaxant effect of resveratrol ( Res) in vivo and in vitro on guinea-pig tracheal smooth muscle, and its potential mechanism. Methods Tracheal strips were isolated and the model of asthmatic guinea-pig was established. The function of Res on antiasthmatic effect was detected. Results Res obviously prolonged theifttency time of asphyxiation collapse induced by histamine (His) and acetyl-choline (Ach) in guinea-pigs, and abrogated the tension of tracheal smooth muscle of precontraction induced by Ach, KC1 and His. The effect of Res on relaxation was attenuated by pretreatment with indomethacin and glibenclamide. Conclusion Res exhibit a significant antiasthmatic and relaxing effect on tracheal smooth muscle of guinea-pig. The mechanism of Res may be related to antagonizing of calcium channel, elevating prostaglandin levels, and opening ATP-sensitive potassium channel.关键词
白藜芦醇/平喘作用/离体气管平滑肌/钙通道/钾通道Key words
resveratrol/ antiasthmatic effect/ isolated tracheal smooth muscle/ potassium channel/ calcium channel分类
医药卫生引用本文复制引用
何冰,王经韵,郑宇翔,徐浚超,陈小夏..白藜芦醇抗喘活性及机制研究[J].广东药学院学报,2012,28(4):423-426,4.
