广东药学院学报2012，Vol.28Issue(4)：456-460,5.DOI:10.3969/j.issn.1006-8783.2012.04.026
P糖蛋白在不同组织中的分布与功能研究进展
Advances in the expression and function of p-glycoprotein in different human tissues
聂昊 1王晖1
作者信息
- 1. 广东药学院中药学院,广东广州510006
- 折叠
摘要
Abstract
P-glycoprotein (P-gp) , as an ATP-binding cassette (ABC) transporter, plays an important role in multidrug resistance (MDR) , maintenance of the body balance and protection of the human tissues. P-gp processes multiple physiological functions, and may become the new diagnosis index and therapeutic target for many diseases. In this paper, we review the recent study on the expression and function of P-gp in different human tissues, and illuminate P-gp from structure, transport mechanism as well as single nucleotide polymorphisms (SNP).关键词
P糖蛋白/多药耐药/单核酸多态性Key words
P-gp/ expression/ function/ structure/ SNP分类
生物学引用本文复制引用
聂昊,王晖..P糖蛋白在不同组织中的分布与功能研究进展[J].广东药学院学报,2012,28(4):456-460,5.
