国际妇产科学杂志2012，Vol.39Issue(3)：220-223,4.
环氧合酶-2与子宫内膜异位症相关性的研究进展
Recent Progress of Cyclooxygenase-2 in the Pathogenesis of Endometriosis
摘要
Abstract
Causes of endometriosis remains unclear up to date,although it is a common benign disease in gynecologic clinic. Recent studies have shown that cyclooxygenase-2 (COX-2) plays an important role in endometriosis .which exhibits an increasing expression in eutopic and ectopic endometrium. COX-2 can suppress apoptosi9 pathway of endometrial cells to promote the growth of endometriotic lesion by regulating the expression of anti-apoptotic proteins and pro-apoptotic enzymes: COX-2 can also facilitate angiogenesis to support the growth and proliferation of endometriotic cells,which is based on the increased expression of angiogenic factors. This article made an review of the role of COX-2 in pathogenesis of endometriosis.关键词
子宫内膜异位症/前列腺素内过氧化物合酶类/血管生成诱导剂/雌激素类Key words
Endometriosis/ Prostaglandin-endoperoxidesynthases/ Angiogenesis inducing agents/ Estrogens引用本文复制引用
孙艳美..环氧合酶-2与子宫内膜异位症相关性的研究进展[J].国际妇产科学杂志,2012,39(3):220-223,4.基金项目
国家自然科学基金资助项目(NNFC81070468) （NNFC81070468）
