国际妇产科学杂志2012，Vol.39Issue(3)：281-283,后插1,4.
丝蛋白涂层轻质聚丙烯网片对兔腹壁疝模型组织学反应的影响
Histologic Response of Silk Protein-coated and Noncoated Low-weight Polypropylene in an Abdominal Hernia Rabbit Model
摘要
Abstract
Objective: The purpose of this study was to determine whether the host tissue response in the abdominal hernia rabbit model differs in 2 polypropylene meshes (coated and noncoated). Methods:24 piece of two different kind polypropylene meshes Gynemesh(R) and Aspide(R) G819Pmesh (coated and noncoated,6 foreach Group) 30 mmx30mm size for each were surgically implanted in six abdominal hernia rabbit model which had six abdominal wall defects for each. Four abdominal wall defects for Coated/noncoated Gynemesh(R) and G819P mesh,two left as the control. Animas were killed 30 (n=2),60 (n=2)and 90 (n=2) days after surgery. Full -thickness sections of abdominal wall were evaluated included macroscopical examination,histological and immunohistochemical analysis ,for example,inflammation,neovascularization, fibroblastic proliferation and collagen formation. Results:Erosion of meshes did not occur in all animals, silk protein-coated low-weight polypropylene meshes induced a mild inflammatory response with minimal fibrosis and good host tissue incorporation within the grafts. Few apoptotic and necrotizing cell were found in noncoated meshes. Conclusions:Coated meshes elicit a mild foreign body reaction, minimal fibrotic response and good host tissue incorporation within the grafts, reducing the inflammatory reaction, fibrosis ,tissue adhesion and the generation of mesh-related complication.关键词
骨盆底/脱垂/腹壁/丝素蛋白质类/聚丙烯/材料试验/生物相容性材料/兔Key words
Pelvic floor/Prolapse/ Abdominal wall/Fibroins/Polypropylenes/Materials testing/Biocompatible materials / Rabbits引用本文复制引用
张荣,吴氢凯,罗来敏..丝蛋白涂层轻质聚丙烯网片对兔腹壁疝模型组织学反应的影响[J].国际妇产科学杂志,2012,39(3):281-283,后插1,4.基金项目
上海市卫生局科研基金资助项目(2006057) （2006057）
上海交通大学"医工(理)交叉研究基金"项目(YG2010MS47) （理）
