国际神经病学神经外科学杂志2012，Vol.39Issue(3)：224-228,5.
癫痫患者神经元特异性烯醇化酶和胰岛素样生长因子1的变化及临床意义
Serum neuron specific enolase and insulin-like growth factor-1 levels in patients with epilepsy
高艳波 1张晖 2王宝军 2宁涛 1朱燕 1杨红燕1
作者信息
- 1. 包头市中心医院内分泌科,内蒙古包头市014000
- 2. 包头市中心医院神经内科,内蒙古包头市014000
- 折叠
摘要
Abstract
Objective To study serum levels of neuron specific enolase (NSE) and insulin-like growth factor-1 (IGF-1) in patients with epilepsy and their significance. Methods Sixty-three patients with idiopathic epilepsy were enrolled in this study. Serum NSE and IGF-1 levels were determined using ECLIA and ELBA within 3 days after seizure attacks. Thirty-seven healthy volunteers served as control group matched with age and sex to the epilepsy group. Results Serum NSE and IGF-1 levels increased significantly in the epilepsy group compared with the control group (P <0. 05). The area under the ROC curve of serum NSE and IGF-1 was 0. 767 and 0. 663 respectively. Serum NSE level was positively correlated with serum IGF-1 level (r = 0. 379, P < 0. 01) in the epilepsy group. Conclusions Serum NSE and IGF-1 levels increase within 3 days after seizure attacks, suggesting that they might be used as early biochemical indicators of seizure-induced brain damage and neuroprotection starting. A positive correlation between serum NSE and IGF-1 levels indicates that they might participate in the process of seizures together.关键词
癫痫/脑损伤/神经保护/神经元特异性烯醇化酶/胰岛素样生长因子1Key words
epilepsy/ brain damage/ neuroprotection/ neuro specific enolase/ insulin-like growth factor-1引用本文复制引用
高艳波,张晖,王宝军,宁涛,朱燕,杨红燕..癫痫患者神经元特异性烯醇化酶和胰岛素样生长因子1的变化及临床意义[J].国际神经病学神经外科学杂志,2012,39(3):224-228,5.
