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外周血白细胞端粒长度与脑梗死的相关性研究

姜昕 黄四春 郭毅

神经损伤与功能重建2012,Vol.7Issue(5):324-326,386,4.
神经损伤与功能重建2012,Vol.7Issue(5):324-326,386,4.DOI:10.3870/sjsscj.2012.05.004

外周血白细胞端粒长度与脑梗死的相关性研究

Association of Telomere Length with Cerebral Infarction

姜昕 1黄四春 2郭毅1

作者信息

  • 1. 暨南大学第二临床医学院心内科,广东,深圳,518020
  • 2. 暨南大学第二临床医学院神经内科,广东,深圳,518020
  • 折叠

摘要

Abstract

Objective:To investigate association of telomere length and cerebral infarction. Methods: Seventy patients with ischemic strokes were recruited for the study and 70 healthy ones were treated as the controls. Leukocyte telomere length was measured with real-time Polymerase Chain Reactions in all subjects. Blood Lipids, blood glucose, high-sensitivity C-reactive protein, blood pressure were measured. Results: The mean leukocyte telomere length of the patients was significantly shorter than that in the controls [(0. 98 ± 0. 84)&(2. 05 ± 0. 98),P<0. 001]. Conclusion: The shorten telomere length is related to cerebral infarction.

关键词

端粒长度/脑梗死/动脉粥样硬化

Key words

telomere length/ cerebral infarction/ atherosclerosis

分类

医药卫生

引用本文复制引用

姜昕,黄四春,郭毅..外周血白细胞端粒长度与脑梗死的相关性研究[J].神经损伤与功能重建,2012,7(5):324-326,386,4.

基金项目

广东省医学科研基金(No.A2009589) (No.A2009589)

神经损伤与功能重建

OACSTPCD

1001-117X

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