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介电材料辅助的微波冷冻干燥的数值模拟

王维 许英梅 马鸿信 陈国华

高校化学工程学报2012,Vol.26Issue(4):575-580,6.
高校化学工程学报2012,Vol.26Issue(4):575-580,6.

介电材料辅助的微波冷冻干燥的数值模拟

Numerical Simulation on Freeze Drying with Dielectric Material Assisted Microwave Heating

王维 1许英梅 2马鸿信 1陈国华3

作者信息

  • 1. 大连民族学院生命科学学院,辽宁大连116600
  • 2. 香港科技大学化学与生物分子工程系,香港
  • 3. 北京航空航天大学航空发动机气动热力国家重点实验室,北京100191
  • 折叠

摘要

Abstract

The effects of the dielectric material on the microwave freeze-drying process were theoretically studied by mathematically solving the heat and mass transfer model considering the hygroscopic effect with a moving boundary in the porous media. Sintered silicon carbide (SiC) was used as the dielectric material, and the mannitol, a typical pharmaceutical excipient, was selected as the solute in aqueous solution. Simulation results show that the dielectric material can significantly enhance the microwave freeze drying rate under the experimental operating conditions, especially when the solid content in the freeze dried solution is very low or the solid product has a very small dielectric loss factor. Comparisons of the drying curves display good agreements between experimental measurements and model predictions. Based on the profiles of ice saturation and temperature, mechanisms of heat and mass transfer inside the material were analyzed, and the drying rate-controlling factor was discussed.

关键词

微波冷冻干燥/介电材料/干燥曲线/多孔介质/传热传质

Key words

microwave freeze drying/ dielectric material/ drying curve/ porous media/heat and mass transfer

分类

化学化工

引用本文复制引用

王维,许英梅,马鸿信,陈国华..介电材料辅助的微波冷冻干燥的数值模拟[J].高校化学工程学报,2012,26(4):575-580,6.

基金项目

国家自然科学基金(21076042/B060302) (21076042/B060302)

香港研资局(RGC)基金(HKUST 600704/C4586) (RGC)

大连民族学院自主科研基金(DC12010209). (DC12010209)

高校化学工程学报

OA北大核心CSCDCSTPCD

1003-9015

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