南方农业学报2012，Vol.43Issue(6)：869-872,4.DOI:10.3969/j:issn.2095-1191.2012.06.869
鱼用口服疫苗免疫佐剂研究进展
Advance in oral vaccine immune adjuvant for fish
摘要
Abstract
Though adjuvant itself does not possess antigen characteristics, when it is used before or together with antigen, it can fortify non-specific immunity ability and immunogenicity to the antigen. Mechanism of oral vaccine immune adjuvant for fishes and the current application status of major adjuvants including cholera toxin (CT) , heat-labile enterotox-in (LT) and cytokine were reviewed in the paper. Several problems were found such as lagged mechanism research, ignorance to particularity of intestinal mucosal immunity, high cost, and safety, etc. To stimulate sound development of aqua-culture industry, a slew of measures should be adopted including sustaining researches on mechanism of intestinal mucosal immunity and oral vaccine immune adjuvant, optimization of immunizing dose and procedure of oral vaccine immune adjuvant, decreasing development and research cost, developing cheaper and safer oral vaccine immune adjuvant, so enhancing its safety to promote health development of aquaculture industry.关键词
鱼用口服疫苗/免疫佐剂/霍乱毒素/大肠杆菌不耐热肠毒素/细胞因子/应用现状Key words
oral vaccine for fish/ adjuvant/ cholera toxin (CT)/ heat-labile enterotoxin(LT)/ cytokine/ application status分类
农业科技引用本文复制引用
黄钧,施金谷,陈明,黄艳华,温华成,彭民毅,王瑞,梁万文..鱼用口服疫苗免疫佐剂研究进展[J].南方农业学报,2012,43(6):869-872,4.基金项目
广西科学研究与技术开发计划项目(桂科攻1123006-4) （桂科攻1123006-4）
