广西师范大学学报（自然科学版）2012，Vol.30Issue(2)：78-82,5.
6-取代1-氮杂苯并蒽酮衍生物的合成及抗肿瘤活性研究
Synthesis and Antitumor Activity of 6-Substituted 1-Azabenzanthrone
摘要
Abstract
A series of novel 6-Substituted 1-Azabenzanthrone derivatives 3a~3e had been synthesized based on double helix DNA. All the target compounds were characterized by ESI-MS,'H NMR and element analysis. The interaction of derivatives with calf thymus DNA was performed by UV spectra. The in vitro cytotoxicity of derivatives for five cell lines (HepG2,SGC-7901,SW480,786-O and NCI-H460) was evaluated using MTT method. The experimental results indicated that the derivatives could intercalate calf thymus DNA and showed moderate cytotoxicity against different tumor cell lines.关键词
氧化异阿朴菲衍生物/DNA/抗肿瘤/合成Key words
oxoisoaporphine derivatives /DNA/ antitumor/ synthesis分类
化学化工引用本文复制引用
唐煌,王志宇,钟书明,覃江克..6-取代1-氮杂苯并蒽酮衍生物的合成及抗肿瘤活性研究[J].广西师范大学学报（自然科学版）,2012,30(2):78-82,5.基金项目
国家自然科学基金资助项目(21002015) （21002015）
广西师范大学博士启动基金资助项目 （）
