郑州大学学报（医学版）2012，Vol.47Issue(4)：491-493,3.DOI:10.3969/j.issn.1671-6825.2012.04.021
不同分子亚型乳腺浸润性导管癌组织中Sox2和Oct4蛋白的表达
Expressions of Sox2 and Oct4 proteins in different molecular subtypes of breast invasive intraductal cancer tissue
摘要
Abstract
Aim;To investigate the expressions of tumor stem cell markers Sox 2 and Oct4 in different molecular subtypes of breast invasive intraductal cancer . Methods:The expressions of Sox2 and Oct4 protein in 120 cases of breast invasive intraductal cancer ( Luminal A 45 cases ,Luminal B 29 cases ,HER-2 overexpression 27 cases ,Basal-like 19 cases) tissues were detected by immunohistochemistry SP method . ReSUltS;The positive expression rates of Sox2 and Oct4 protein a- mong the 4 groups had significant differences ( H = 27. 688 ,50. 737 , P < 0. 001 ) , which were much higher in Basal -like breast cancer tissue and much lower in Luminal A breast cancer tissue (P < 0. 05). There was positive relationship between the expressions of Sox2 and Oct4 in breast invasive intraductal cancer tissue (rs =0. 506 ,P < 0. 001). Conclusion: The expressions of Sox2 and Oct4 are closely correlated with the clinical manifestations of molecular subtypes of breast invasive in -traductal cancer.关键词
Sox2,Oct4/分子亚型/乳癌Key words
Sox2/ Oct4/ molecular subtype / breast cancer分类
医药卫生引用本文复制引用
史立纲,吕新全,燕丽,徐正顺,李惠翔..不同分子亚型乳腺浸润性导管癌组织中Sox2和Oct4蛋白的表达[J].郑州大学学报（医学版）,2012,47(4):491-493,3.基金项目
国家自然科学基金资助项目 30971149 （）
