郑州大学学报（医学版）2012，Vol.47Issue(4)：512-515,4.DOI:10.3969/j.issn.1671-6825.2012.04.028
脑白质病变对认知功能的影响
Influence of cerebral white matter lesions on cognitive function
摘要
Abstract
Aim; To investigate the cognitive function impairment of patients with cerebral white matter lesion (WML) at different extent and different location. Methods: According to MRI T2 weighted -imaging and FLAIR imaging ,75 patients were first classified into 3 subgroups (mild, moderate , and severe) depending on the extent , then were classified into 2 subgroups (periventricular lesions and deep WML ) depending on the location. Thirty normal people were regarded as control group. Cognitive performance was assessed using the Montreal Cognitive Assessment ( MoCA). ReSUltS: Compared with control , WML group had significantly low scores in total MoCA score , visual spatial, executive function , language , memory and o-rientation. Moderate and severe subgroups had significantly low scores in attention,calculation and abstraction ; severe subgroup had significantly low scores in naming (P < 0. 05). The periventricular lesion subgroup had significantly low scores in total MoCA score , calculation , language , abstraction, memory and orientation , and insignificantly high scores in visual spa -tial, executive function or attention compared with deep WML subgroup . Conclusion: Patients with WML undergo cognitive function impairment, especially in visual spatial, executive function , language , abstraction, memory and orientation. Periventricular and deep WML may have different influence on cognitive function .关键词
脑白质病变/认知功能/蒙特利尔认知评估量表Key words
white matter lesion / cognitive function / Montreal Cognitive Assessment分类
医药卫生引用本文复制引用
闫文军,黄丽娜,富奇志,连立飞,杜敢琴..脑白质病变对认知功能的影响[J].郑州大学学报（医学版）,2012,47(4):512-515,4.基金项目
洛阳市卫生局科技攻关计划基金资助项目 0901066A （）
