摘要
Abstract
Aim: To explore the inhibitory effect and mechanism of atorvastatin on left ventricular hypertrophy ( LVH) in spontaneous hypertension rats (SHRs). Methods: Twenty-four SHRs were randomly divided into the treatment and control groups. The treatment group were treated with atorvastatin for 10 weeks at dose of 30 mg/ ( kg· d) , and rats in the control group were treated with distilled water of the same volume . The SBP,the LVWI and the level of TGF-β1 and Ang Ⅱ were determined by ELISA after ten weeks. ReSUltS; Compared with the treatment group , the LVWI, and the levels of TGF-βl and Ang Ⅱ in left ventricular tissue and blood in the control group were higher , and the differences were significant (t = 9. 798 ,3. 221 ,2. 602 ,3. 483 ,and 3. 394,P <0. 05 ). The value of LVM1 was positively correlated with the level of Ang II and TGF-βl in left ventricular tissue ( r = 0. 634 and 0. 579 ,P = 0. 024 and 0. 015 ). Conclusion : Atorvastatin can inhibit LVH of the SHRs, and the mechanism may be related to its inhibiting the expression of AngⅡ and TGF-β1.关键词
阿托伐他汀/自发性高血压/心室肥厚/转化生长因子β1/血管紧张素Ⅱ/大鼠Key words
atorvastatin / spontaneous hypertension / ventricular hypertrophy / transforming growth factor-βl /AngⅡ /rat分类
医药卫生
