摘要
Abstract
Objective: To explore the effect of the therapy of bushen huoxue touxie on relapse of ankylosing spondylitis. Methods: Sixty patients with AS were randomly divided into two groups,30 patients in the treatment group were treated with BuShenHuoXueTouXieFang and diclofenac sodium. 30 patients in the control group were treated with SSZ and diclofenac sodium. After 12 weeks, patients who at-tained an improvement of > ASAS20, were followed up until relapse or 28 weeks after stopping using diclofenac sodium. The duration of relapse,Bath AS disease activity index(BAS-DAI) ,Bath AS functional index(BASFI) .Visual Analogue Scale(VAS)of spinal pain.e-valuation of patients, the erythrosedi mentation(ESR) ,C-reactive protein(CRP) ,as well as adverse effect of medicine were observed. Results:51 patients who attained an improvement of > ASAS20 at week 12 were followed using a definition of relapse. The duration of relapse of treatment group was 14 weeks, however that in the control group was 10 weeks. The rates of relapse in the treatment group and control group were 51.8% ,79. 1% ,respectively,The differents betweent the two groups were significantly(P <0.05). The treatment group also showed better results on down-regulation of ESR, CRP level and improvement of BASDAI, BASF] and other indexes after treatment( P < 0.05 ). Conclusion: After discontinuing the diclofenac sodium keeping the initial medications almost patients completed disease relapsed within short times. Bushen huoxue touxiefang could prolong the duration of remission, but less adverse reaction in the treatment of AS.关键词
强直性脊柱炎/补肾活血透邪法/病情复发/柳氮磺胺吡啶/双氯芬酸钠/大偻/脊痹Key words
ankylosing spondylitis/bushen huoxue touxie method/recurrence/Sulfasalazine/diclofenac sodium/dyphosis/ridge paralysis分类
医药卫生
