化工学报2012，Vol.63Issue(8)：2469-2476,8.DOI:10.3969/j.issn.0438-1157.2012.08.019
逆向法测定酮洛芬对映体在Chiralpak AD柱上的吸附等温线
Determination of adsorption isotherms of ketoprofen enantiomers on Chiralpak AD column by inverse method
摘要
Abstract
The determination of competitive adsorption isotherm is of great importance for model-based design and optimization of chromatographic separation processes, especially for the simulated moving bed due to its intrinsic complexity. The competitive adsorption isotherms of ketoprofen enantiomers on an amylose-based chiral stationary phase (Chiralpak AD) at 25℃ were determined in this study by the application of the inverse method. Elution profiles of various racemic feed signals were measured on a preparative chromatography column with a precise temperature control system. The parameters of isotherm models were determined by fitting the experimental elution profiles. The mass balance for component in the column was described by equilibrium-dispersive model. In the fitting procedure, isotherm parameters were searched over a wide range in the parametric space with the non-dominated sorting genetic algorithm (NSGA-II ) and polished with the Levenberg-Marquardt algorithm. Four competitive adsorption isotherm models were compared based on the fitting to the experimental data. Bi-Langmuir model with 5 parameters gave the best results. In order to validate this model and the model parameters, independent overloaded profiles with different concentrations and amount of feed were measured and compared with the model. Quantitatively good agreement was observed.关键词
竞争吸附等温线/酮洛芬对映体/逆向法/模拟移动床色谱Key words
competitive adsorption isotherm-, ketoprofen enantiomers/ inverse method/ SMB分类
化学化工引用本文复制引用
朱磊,徐进,孙玉高,刘玉明,余卫芳..逆向法测定酮洛芬对映体在Chiralpak AD柱上的吸附等温线[J].化工学报,2012,63(8):2469-2476,8.基金项目
国家自然科学基金项目(21106108). （21106108）
