湖南中医药大学学报2012，Vol.32Issue(7)：15-18,4.DOI:10.3969/j.issn.1674-070X.2012.07.005.015.04
湿痹通对大鼠急性痛风性关节炎模型抗炎作用机制的探讨
Anti-inflammatory mechanism of Shibitong priscription on the acute gouty arthritis rats
摘要
Abstract
Objective To observe the anti-inflammtory mechanism of Shibitong prscription on rats with acute gouty arthritis. Methods 40 SPF Wistar rats were randomly divided into 5 groups as follows: blank group, model group, colchicine group, Shibitong high -dose group and low-dose group, 8 rats in each group. Rat model of acute gouty arthritis was replicated by intra-articular injection of monosodium urate crystal suspension inside the ankle joint. Inflammation index and dysfunction index were observed after modeled 8 h and 72 h. IL-1β and IL-1R expression levels in serum and joint soft tissues were detected. Results The inflammation index and dysfunction index, expression levels of IL-1β and IL-1R in serum and joint soft tissues of the model group were higher than those of other groups (P<0.05), and expression levels of IL-1β and IL-1R in joint soft tissues of the Shibitong high-dose group were higher than those of Shiti-tong low-dose group (P<0.05). Conclusion The inflammatory effects in rat with acute gouty arthritis can be improvement by treating Shibitong priscription and the Shibitong effects may be related with the decreased expression levels of IL-1β and IL-1R in serum and joint soft tissues.关键词
急性痛风性关节炎/湿痹通/炎症细胞因子/大鼠/七叶莲/土茯苓Key words
acute gouty arthritis/ Shibitiong priscription/ inflammatory cytokines/ rat/ Schef-flera arboricola Hagata/ Glabrous Greenbrier Rhizome分类
医药卫生引用本文复制引用
姚红,杨飞燕,刘昌盛,陈瑞旦,童娟..湿痹通对大鼠急性痛风性关节炎模型抗炎作用机制的探讨[J].湖南中医药大学学报,2012,32(7):15-18,4.基金项目
广东省自然科学基金资助项目(9451018201003652) （9451018201003652）
广东省中医药局资助项目(2009253). （2009253）
